Reddy C P, Arnett J D
J La State Med Soc. 1989 May;141(5):45-8.
Ventricular arrhythmias can be categorized into three broad groups, namely, benign, malignant, and potentially malignant based on the presence or absence and the severity of underlying heart disease. The benign group does not require treatment, the benefits of treatment in the potentially malignant group are unproven, and the malignant group benefits the most from antiarrhythmic therapy. Because there is no ideal antiarrhythmic drug and all drugs have limitations, selection of an antiarrhythmic drug should be based on the therapeutic goal and the relative efficacies and toxicity profiles of various agents. In the absence of demonstrated beneficial effect from suppression of ventricular arrhythmia in many cardiac patients, antiarrhythmic drug therapy should be confined to patients with serious symptoms, patients with recurrent sustained ventricular tachycardia, and those resuscitated from cardiac arrest.
室性心律失常可根据潜在心脏病的有无及严重程度大致分为三大类，即良性、恶性和潜在恶性。良性组无需治疗，潜在恶性组治疗的益处尚未得到证实，而恶性组从抗心律失常治疗中获益最大。由于没有理想的抗心律失常药物，且所有药物都有局限性，抗心律失常药物的选择应基于治疗目标以及各种药物的相对疗效和毒性特征。在许多心脏病患者中，若未显示出抑制室性心律失常有有益效果，则抗心律失常药物治疗应限于有严重症状的患者、复发性持续性室性心动过速患者以及心脏骤停后复苏的患者。
