Effect of Paclitaxel on Antitumor Activity of Cyclophosphamide: Study on Two Transplanted Tumors in Mice.

作者信息

Kaledin V I, Nikolin V P, Popova N A, Pyshnaya I A, Bogdanova L A, Morozkova T S

机构信息

Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

Novosibirsk State University, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2015 Nov;160(1):81-3. doi: 10.1007/s10517-015-3103-6. Epub 2015 Nov 24.

Antitumor effect of paclitaxel used as the monotherapy or in combination with cyclophosphamide was studied on CBA/LacSto mice with transplanted LS and RLS tumors characterized by high (LS) and low (RLS) sensitivity to cyclophosphamide. The therapeutic effects of cyclophosphamide and paclitaxel were summed in animals with drug-resistant RLS tumor, while combined use of these drugs in LS tumor highly sensitive to the apoptogenic effect of cyclophosphamide was no more effective than cyclophosphamide alone.