[Wnt信号通路在脑功能调节中的作用]

[A Role of the Wnt Signaling in the Regulation of Brain Function].

作者信息

Gurskaya O Ya, Dobryakova Y V, Markevich V A

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2015 Jul-Aug;65(4):387-99.

Abstract

The review describes the Writ signaling pathway participation in the embryonic development, such as cell specification, migration and polarity. Recent studies have shown that the Wnt pathway plays one of the key roles in the processes of synaptic plasticity and memory formation. In this review there are evidences of the Wnt cascade involvement in the modulation of synaptic efficacy at both pre- and postsynaptic levels. Here we analyze the role of Wnt ligands in synaptic plasticity and behavior. Finally, we describe that components of Wnt pathways are involved in the development of major neurological and psychiatric disorders, including a neuroprotective role of Wnt proteins in the pathogenesis of Alzheimer's disease.

摘要

这篇综述描述了Wnt信号通路在胚胎发育中的参与情况，如细胞特化、迁移和极性。最近的研究表明，Wnt通路在突触可塑性和记忆形成过程中发挥着关键作用之一。在这篇综述中，有证据表明Wnt级联反应在突触前和突触后水平对突触效能的调节中发挥作用。在这里，我们分析Wnt配体在突触可塑性和行为中的作用。最后，我们描述了Wnt通路的组成部分参与了主要神经和精神疾病的发生发展，包括Wnt蛋白在阿尔茨海默病发病机制中的神经保护作用。