Tepekoy Filiz, Akkoyunlu Gokhan, Demir Ramazan
Department of Histology and Embryology, Medical Faculty, Akdeniz University, Antalya, 07070, Turkey.
J Assist Reprod Genet. 2015 Mar;32(3):337-46. doi: 10.1007/s10815-014-0409-7. Epub 2014 Dec 24.
Wnt family members are best known for their roles in cell fate determination, differentiation, proliferation and apoptosis during embryonic development. Wnt signaling becomes effective during these cellular processes through the proper interaction between its ligands, receptors, effectors and inhibitors. Here we review Wnt signaling in terms of embryonic development to the blastocyst stage implantation with emphasis on endometrial changes that are critical for receptivity in the uterus. The relationship between Wnt signaling and implantation clearly reveals that, Wnt family members are critical for both early embryonic development and changing of the endometrium before implantation. Specific Wnt signaling pathway members are demonstrated to be critical for endometrial events such as decidualization and endometrial gland formation in addition to cyclic changes in the endometrium controlled by reproductive hormones. In conclusion, specific roles of Wnt members and associated factors for both uterine function and embryonic development should be further investigated with respect to the efficiency of human ARTs.
Wnt家族成员以其在胚胎发育过程中的细胞命运决定、分化、增殖和凋亡中的作用而闻名。Wnt信号通过其配体、受体、效应器和抑制剂之间的适当相互作用在这些细胞过程中发挥作用。在这里，我们从胚胎发育到囊胚期着床来综述Wnt信号，重点关注对子宫接受性至关重要的子宫内膜变化。Wnt信号与着床之间的关系清楚地表明，Wnt家族成员对早期胚胎发育和着床前子宫内膜的变化都至关重要。除了由生殖激素控制的子宫内膜周期性变化外，特定的Wnt信号通路成员被证明对子宫内膜事件如蜕膜化和子宫内膜腺体形成至关重要。总之，关于人类辅助生殖技术的效率，应进一步研究Wnt成员及其相关因子对子宫功能和胚胎发育的特定作用。
