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当代冠状动脉旁路移植术患者手术结局的种族差异与医院和医生特征及护理过程的关联。

Association of Hospital and Physician Characteristics and Care Processes With Racial Disparities in Procedural Outcomes Among Contemporary Patients Undergoing Coronary Artery Bypass Grafting Surgery.

机构信息

From Duke Clinical Research Institute and Duke University Medical Center, Durham, NC (R.H.M., S.S., S.M.O'B., E.D.P.); Massachusetts General Hospital, Boston (D.M.S.); The Society of Thoracic Surgeons, Chicago, IL (F.H.E.); and John Hopkins University, Baltimore, MD (J.P.J.).

出版信息

Circulation. 2016 Jan 12;133(2):124-30. doi: 10.1161/CIRCULATIONAHA.115.015957. Epub 2015 Nov 24.

Abstract

BACKGROUND

Previous studies have reported that black patients undergoing coronary artery bypass surgery had worse outcomes than white patients, even after accounting for patient factors. The degree to which clinician, hospital, and care factors account for these outcome differences remains unclear.

METHODS AND RESULTS

We evaluated procedural outcomes in 11,697 blacks and 136,362 whites undergoing isolated coronary artery bypass surgery at 663 Society of Thoracic Surgery Database participating sites (January 1, 2010 to June 30, 2011) adjusted for patients' clinical and socioeconomic features, hospital and surgeon effects, and care processes (internal mammary artery graft and perioperative medications use). Relative to whites, blacks undergoing coronary artery bypass surgery were younger, yet had higher comorbidities and more adverse presenting features. Blacks were also more likely to be treated at hospitals with higher risk-adjusted mortality. The use of internal mammary artery was marginally lower in blacks than in whites (93.3% versus 92.2%, P<0.0001). Unadjusted mortality and major morbidity rates were higher in blacks than in whites (1.8% versus 2.5%, P<0.0001) and (13.6% versus 19.4%, P<0.0001), respectively. These racial differences in outcomes narrowed but still persisted after adjusting for surgeon, hospital, and care processes in addition to patient and socioeconomic factors (odds ratio, 1.17; 95% confidence interval, 1.00-1.36 and odds ratio, 1.26; 95% confidence interval, 1.19-1.34, respectively).

CONCLUSIONS

The risks of procedural mortality and morbidity after coronary artery bypass surgery were higher among black patients than among white patients. These differences were in part accounted for by patient comorbidities, socioeconomic status, and surgeon, hospital, and care factors, as well, as suggested by the reduction in the strength of the race-outcomes association. However, black race remained an independent predictor of outcomes even after accounting for these differences.

摘要

背景

既往研究报告,行冠状动脉旁路移植术的黑人患者预后较白人患者差,即使在考虑患者因素后依然如此。但目前尚不清楚临床医生、医院和护理因素在多大程度上导致了这些结局差异。

方法和结果

我们在 663 个参与胸外科学会数据库的机构(2010 年 1 月 1 日至 2011 年 6 月 30 日)中,评估了 11697 例黑人患者和 136362 例白人患者的手术结局,这些患者的临床和社会经济特征、医院和外科医生的影响以及护理流程(内乳动脉移植物和围手术期药物使用)都经过了调整。与白人患者相比,行冠状动脉旁路移植术的黑人患者更年轻,但合并症更多,临床表现更差。黑人患者也更有可能在风险调整死亡率较高的医院接受治疗。黑人患者使用内乳动脉的比例略低于白人患者(93.3%比 92.2%,P<0.0001)。未校正的死亡率和主要并发症发生率在黑人患者中高于白人患者(1.8%比 2.5%,P<0.0001;13.6%比 19.4%,P<0.0001)。在调整了患者和社会经济因素、外科医生、医院和护理流程后,这些结局方面的种族差异虽然缩小,但仍持续存在(比值比,1.17;95%置信区间,1.001.36;比值比,1.26;95%置信区间,1.191.34)。

结论

行冠状动脉旁路移植术的黑人患者的手术死亡率和发病率风险高于白人患者。这些差异部分归因于患者的合并症、社会经济地位以及外科医生、医院和护理因素,这从种族与结局关联强度的降低中可以看出。然而,即使考虑到这些差异,黑人种族仍然是结局的独立预测因素。

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