Sadeghi Roxana, Miri Reza, Kachoueian Naser, Sistanizad Mohammad, Hassanpour Rezvan
Prevention of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cardiology, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
ARYA Atheroscler. 2023 Jan;19(1):1-11. doi: 10.48305/arya.2022.26640.2819.
Gender impacts pre-, intra-, and postoperative parameters and outcomes following coronary artery bypass graft (CABG) with conflicting results. This study aimed to identify differences in preoperative, intraoperative, and postoperative parameters. It also seeks to compare the postoperative complications and mortality between two genders who had CABG surgery.
This prospective observational study included patients who had isolated CABG and were divided based on gender. Demographic information, underlying comorbidities, drug history, clinical and laboratory data at the time of referral, operative characteristics, postoperative variables, and mortality outcomes were tracked during hospitalization and six months after discharge.
Three hundred twenty patients were enrolled in the study during its duration. 71% were male. Women were older (62.40±9.03 vs. 59.99±9.81 years, p= 0.011) and had more dyslipidemia (p=0.003), hypertension (p=0.000), and diabetes (p=0.001), whereas men admitted with more myocardial infarction (MI) (p=0.011) and had lower Ejection fraction (EF) (p=0.001). They also had lower EF post-surgery (p <0.001) and six months after discharge (p = 0.006). However, the number of vessels involved was not different between genders (p=0.589), but the number of grafts was higher in men (p=0.008).There was no statistically significant difference in overall mortality rates between the two groups (4.42% and 6.38% in men and women, respectively, p= 0.464).
The women had more underlying comorbidities than men. Furthermore, there were some differences in the intra-operative parameters and postoperative complications between the two genders, but there was no difference in postoperative mortality in our setting.
性别对冠状动脉旁路移植术（CABG）术前、术中和术后的参数及结果均有影响，但其结果存在矛盾。本研究旨在确定术前、术中和术后参数的差异。同时，本研究还旨在比较接受CABG手术的男性和女性术后并发症及死亡率。
本前瞻性观察性研究纳入了接受单纯CABG手术的患者，并根据性别进行分组。在住院期间及出院后6个月，对患者的人口统计学信息、基础合并症、用药史、转诊时的临床和实验室数据、手术特征、术后变量及死亡率结果进行跟踪。
在研究期间，共有320例患者入组。其中71%为男性。女性年龄更大（62.40±9.03岁 vs. 59.99±9.81岁，p = 0.011），血脂异常（p = 0.003）、高血压（p = 0.000）和糖尿病（p = 0.001）的发生率更高，而男性心肌梗死（MI）发生率更高（p = 0.011），射血分数（EF）更低（p = 0.001）。术后及出院6个月后，男性的EF也更低（术后p < 0.001，出院6个月后p = 0.006）。然而，两性之间受累血管数量无差异（p = 0.589），但男性的移植血管数量更多（p = 0.008）。两组的总体死亡率无统计学差异（男性和女性分别为4.42%和6.38%，p = 0.464）。
女性的基础合并症比男性更多。此外，两性在术中参数和术后并发症方面存在一些差异，但在我们的研究中，术后死亡率无差异。
