Naha L, Nadour K, Iken M, Lmimouni B
Service de parasitologie-mycologie, CeDoc faculté de Médecine et de Pharmacie Mohammed V, hôpital Militaire Mohammed V de Rabat, Rabat, Maroc.
Service d'ORL et CCF, hôpital Militaire Moulay Ismail de Meknès, Meknès, Maroc.
J Mycol Med. 2015 Dec;25(4):293-6. doi: 10.1016/j.mycmed.2015.09.007. Epub 2015 Oct 23.
Definition, diagnosis and treatment of allergic fungal sinusitis remain difficult and controversial despite the increasing number of publications. We report a case of an allergic fungal sinusitis with a review of the literature.
A 45-year-old man consulted for sinusal polyposis resistant to steroid therapy, clinical examination objectified bilateral nasal polyps and covered with scabs. CT scan of the sinuses disclosed a sinuse filled with a tissue density material containing air with lysis of the left maxillary sinus, hypereosinophilia, the IgE levels were high. Finally, mycological investigation allowed the identification of Aspergillus fumigatus. The patient underwent total ethmoidectomy, histological study found an allergic mucin and inflammatory mucosa with numerous eosinophils. The postoperative course was good and the patient was given oral steroids. The clinical and radiological evolution was favorable without recurrence with a follow-up of three years.
A set of clinical, radiological, histopathological, immunoallergological and mycological criteria is necessary for precise diagnosis and to avoid fungal drift. The treatment is based on endoscopic surgery associated with corticosteroid.
尽管出版物数量不断增加,但变应性真菌性鼻窦炎的定义、诊断和治疗仍然困难且存在争议。我们报告一例变应性真菌性鼻窦炎病例并对文献进行综述。
一名45岁男性因对类固醇治疗耐药的鼻窦息肉前来就诊,临床检查发现双侧鼻息肉且表面覆盖痂皮。鼻窦CT扫描显示一个充满含气组织密度物质的鼻窦,左侧上颌窦骨质溶解,嗜酸性粒细胞增多,IgE水平升高。最后,真菌学检查鉴定出烟曲霉。患者接受了全筛窦切除术,组织学研究发现变应性黏液和伴有大量嗜酸性粒细胞的炎性黏膜。术后过程顺利,患者接受了口服类固醇治疗。随访三年,临床和影像学进展良好,无复发。
一套临床、放射学、组织病理学、免疫变应学和真菌学标准对于精确诊断和避免真菌播散是必要的。治疗基于内镜手术联合皮质类固醇。