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[非侵袭性真菌性鼻窦炎(真菌球)——诊断难点]

[Noninvasive fungal sinusitis (fungus ball)--diagnostic difficulties].

作者信息

Babiński Dariusz, Narozny Waldemar, Skorek Andrzej, Rzepko Robert, Stankiewicz Czesław

机构信息

Klinika Chorób Uszu, Nosa, Gardła i Krtani Akademii Medycznej w Gdańsku.

出版信息

Otolaryngol Pol. 2007;61(5):694-7. doi: 10.1016/S0030-6657(07)70508-5.

Abstract

Noninvasive fungal sinusitis (fungus ball) is usually found in one sinus and the most frequently is caused by Aspergillus. Diagnostic criteria are based on histopathology, and fungal cultures are frequently negative. The clinical symptomatology mimics chronic rhinosinusitis and radiology, specially CT and MRI are helpful for making decision of surgery. The authors present 4 cases of fungus ball of the paranasal sinus. In one case clinical symptoms, endoscopic examination of nasal cavity and CT scans suggested foreign body in the maxillary sinus. In other case clinical and radiological evidences made us to thing of neoplasmatic disease of the frontal sinus. In remaining two cases mycetoma was found in the sphenoid sinus. Surgical removal was the treatment in all cases and followed by systemic antifungal therapy in one case because of bone destruction. Histopathology revealed hyphae of Aspergillus without evidence of tissue invasion, fungal cultures in two cases were negative, an in other two Aspergillus fumigatus culture were obtained.

摘要

非侵袭性真菌性鼻窦炎(真菌球)通常局限于一个鼻窦,最常见的致病菌为曲霉菌。诊断标准基于组织病理学检查,真菌培养结果常为阴性。其临床症状与慢性鼻-鼻窦炎相似,影像学检查,尤其是CT和MRI有助于决定是否需要手术治疗。作者报告了4例鼻窦真菌球病例。其中1例的临床症状、鼻腔内镜检查及CT扫描提示上颌窦内有异物。另1例的临床及影像学表现使我们怀疑为额窦肿瘤性疾病。其余2例在蝶窦发现真菌瘤。所有病例均接受了手术切除治疗,其中1例因骨质破坏在术后接受了全身抗真菌治疗。组织病理学检查显示为曲霉菌丝,但无组织侵袭证据,2例真菌培养结果为阴性,另2例培养出烟曲霉菌。

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