de Sumari-de Boer I Marion, van den Boogaard Jossy, Ngowi Kennedy M, Semvua Hadija H, Kiwango Krisanta W, Aarnoutse Rob E, Nieuwkerk Pythia T, Kibiki Gibson S
Department of clinical trials, Kilimanjaro Clinical Research Institute, Dr. I Marion Sumari-de Boer, PO Box 2236, Moshi, Tanzania.
Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
AIDS Behav. 2016 May;20(5):1097-107. doi: 10.1007/s10461-015-1254-0.
HIV infected and tuberculosis (TB) patients need high levels of treatment adherence to achieve optimal treatment outcomes. We conducted a pilot-study on real time medication monitoring (RTMM) in a resource-limited setting. We enrolled five HIV infected and five TB patients from Kilimanjaro, Tanzania. They took their medication using RTMM. When the device was not opened on time, patients received a reminder SMS. After 3 months, we interviewed patients. Six patients (60 %) reached adherence of >95 %. Nine-hundred-twenty-two of 1104 intakes (84 %) were on time. Five-hundred reminders (45 %) were sent, of which 202 (40 %) were incorrect, because of an unstable mobile network. Nine patients found the device helpful and nine mentioned it keeps medication safe. Six patients reported that the size was too big. Five patients mentioned they received incorrect reminders. The device is considered useful in Kilimanjaro. Optimization of the device should consider network connectivity and the size of the device.
感染艾滋病毒和患有结核病的患者需要高度坚持治疗，以实现最佳治疗效果。我们在资源有限的环境中进行了一项实时药物监测（RTMM）的试点研究。我们从坦桑尼亚乞力马扎罗招募了5名感染艾滋病毒的患者和5名结核病患者。他们使用RTMM服药。当设备未按时打开时，患者会收到提醒短信。3个月后，我们对患者进行了访谈。6名患者（60%）的依从性达到了>95%。1104次服药中有922次（84%）按时进行。共发送了500次提醒（45%），其中202次（40%）因移动网络不稳定而有误。9名患者认为该设备有帮助，9名患者提到它能保证药物安全。6名患者报告说设备尺寸太大。5名患者提到他们收到了错误的提醒。该设备在乞力马扎罗被认为是有用的。设备的优化应考虑网络连接性和设备尺寸。
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