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下颌下涎腺基底细胞腺瘤:一例报告及文献复习

Basal Cell Adenoma of Submandibular Salivary Gland: A Case Report and Literature Review.

作者信息

Lambade Pravin N, Rajkhokar Dilpreet, Lambade Dipti

机构信息

Department of Oral and Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, 441110 Maharashtra India ; 14, Nehru Nagar, Near Surendra Nagar Basket Ball Ground, Nagpur, 440022 Maharashtra India.

Department of Oral and Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur, 441110 Maharashtra India.

出版信息

J Maxillofac Oral Surg. 2015 Dec;14(4):999-1003. doi: 10.1007/s12663-014-0709-6. Epub 2014 Oct 8.

Abstract

BACKGROUND

Salivary gland tumours constitute about 3-4 % of all head and neck neoplasms. Approximately 80 % originate in the parotid gland and they are rarely present in the submandibular gland. Basal cell adenoma is a benign epithelial salivary gland tumour that appears to have unique histologic characteristics. The diagnosis of this entity must be established by histological study.

CASE REPORT

The literature revealed only four reported cases of basal cell adenoma of submandibular salivary gland. This article presents a rarely occurring basal cell adenoma as a fifth reported case in submandibular salivary gland in a 23 year old female.

DISCUSSION

A rare case of basal cell adenoma of submandibular salivary gland is reported with clinical features, diagnosis, histopathological features and treatment modalities. When there is involvement of submandibular gland with a tumour the histopathological confirmation is mandatory instead of relying on FNAC and it must be differentiated from pleomorphic adenoma, adenoid cystic carcinoma, adenocarcinoma due to its prognostic implications.

CONCLUSION

Entities like basal cell adenoma can only be established by histopathological examination after excisional biopsy. The treatment done also affects the ultimate prognosis. As such the surgeon has to make his clinical decision based on many factors like history, clinical examination, histopathological examinations, radiological examination and immunohistochemistry study. No single criteria should be relied upon. We recommend to carry out genetic pattern study in a person with basal cell adenoma to rule out pathogenesis and establish a correct diagnosis of it for better understanding and prognosis.

摘要

背景

涎腺肿瘤约占所有头颈部肿瘤的3%-4%。约80%起源于腮腺,很少出现在下颌下腺。基底细胞腺瘤是一种良性上皮性涎腺肿瘤,似乎具有独特的组织学特征。该实体的诊断必须通过组织学研究来确立。

病例报告

文献中仅报道了4例下颌下涎腺基底细胞腺瘤。本文介绍了1例罕见的基底细胞腺瘤,为一名23岁女性下颌下涎腺的第5例报道病例。

讨论

报告了1例罕见的下颌下涎腺基底细胞腺瘤,包括其临床特征、诊断、组织病理学特征和治疗方式。当下颌下腺出现肿瘤时,组织病理学确诊是必要的,而不是依赖细针穿刺抽吸活检(FNAC),并且由于其预后意义,必须将其与多形性腺瘤、腺样囊性癌、腺癌相鉴别。

结论

像基底细胞腺瘤这样的实体只能在切除活检后通过组织病理学检查来确立。所采取的治疗方法也会影响最终预后。因此,外科医生必须根据病史、临床检查、组织病理学检查、放射学检查和免疫组化研究等多种因素做出临床决策。不应仅依赖单一标准。我们建议对基底细胞腺瘤患者进行基因模式研究,以排除发病机制并确立正确诊断,从而更好地理解和判断预后。

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