Lawton Christopher, Acosta Sandra, Watson Nate, Gonzales-Portillo Chiara, Diamandis Theo, Tajiri Naoki, Kaneko Yuji, Sanberg Paul R, Borlongan Cesar V
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.
Neural Regen Res. 2015 Sep;10(9):1359-62. doi: 10.4103/1673-5374.165218.
There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood contains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it enhances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant's susceptibility to both neonatal and age-related diseases.
目前,临床医生和科学家对于脐带结扎的合适时机或最佳时机尚未达成共识。然而,许多临床研究表明,延迟脐带结扎与多种新生儿益处相关,包括血容量增加、输血需求减少、早产儿脑氧合增加以及足月儿缺铁性贫血频率降低。人类脐带血含有大量的干细胞和祖细胞,目前用于治疗几种危及生命的疾病。我们建议鼓励延迟脐带结扎,因为它能增强从胎盘到新生儿的血流,这伴随着有价值的干细胞和祖细胞供应增加,还可能改善血液氧合并增加血容量,从而总体降低婴儿患新生儿疾病和与年龄相关疾病的易感性。