Hsieh Yi-Hsuan, Chiu Wei-Che, Lin Chiao-Fan, Chan Hsiang-Lin, Liang Hsin-Yi, Lee Yena, McIntyre Roger S, Chen Vincent Chin-Hung
Department of Child and Adolescent Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Psychiatry, Cathay General Hospital, Taipei 10630, Taiwan.
PLoS One. 2015 Nov 25;10(11):e0143668. doi: 10.1371/journal.pone.0143668. eCollection 2015.
To our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence.
Using a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan's National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables.
We found antidepressant use did not increase the risk of gastric cancer. The lack of an association between antidepressant prescription and elevated gastric cancer incidence was apparent for across selective serotonin-reuptake inhibitors (SSRIs), tricyclic agents (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), reversible inhibitors of monoamine oxidase A (RIMA), trazodone, mirtazapine and bupropion. There were slightly decreased gastric cancer risks of SSRIs use (≧28 DDD group, adjusted OR = 0.87; 95% CI = 0.78-0.96). Sensitive analysis showed SSRIs, TCAs, and SNRIs did not increase gastric cancer risks significantly even in the group with peptic ulcer history.
An association between antidepressant exposure and gastric cancer was not apparent in this analysis.
据我们所知，尚无流行病学研究报告抗抑郁药暴露与胃癌之间是否存在关联。在此，我们旨在调查抗抑郁药暴露与胃癌发病率之间可能存在的关联。
采用巢式病例对照设计，我们从台湾国民健康保险研究数据库（NHIRD）中确定了26289例胃癌病例和127984名对照。使用条件逻辑回归模型对数据进行分析，并对可能的混杂变量进行调整。
我们发现使用抗抑郁药不会增加患胃癌的风险。在选择性5-羟色胺再摄取抑制剂（SSRI）、三环类药物（TCA）、5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI）、单胺氧化酶A可逆抑制剂（RIMA）、曲唑酮、米氮平和安非他酮中，抗抑郁药处方与胃癌发病率升高之间缺乏关联是显而易见的。使用SSRI有轻微降低胃癌风险的趋势（≧28规定日剂量组，调整后的比值比=0.87；95%可信区间=0.78-0.96）。敏感性分析显示，即使在有消化性溃疡病史的组中，SSRI、TCA和SNRI也不会显著增加胃癌风险。
在本分析中，抗抑郁药暴露与胃癌之间的关联并不明显。
Zotero 插件