微小RNA-190a通过靶向长链非编码RNA treRNA抑制肝癌细胞的上皮-间质转化。
miR-190a inhibits epithelial-mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA.
作者信息
Wang Xinyu, Ren Yanli, Yang Xinyu, Xiong Xiangyu, Han Sichong, Ge Yunxia, Pan Wenting, Zhou Liqing, Yuan Qipeng, Yang Ming
机构信息
State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China; Department of Genetics, Harvard Medical School, Boston, MA, USA.
State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
出版信息
FEBS Lett. 2015 Dec 21;589(24 Pt B):4079-87. doi: 10.1016/j.febslet.2015.11.024. Epub 2015 Nov 19.
treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a-treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.
treRNA是一种参与癌症进展的长链非编码RNA（lncRNA）。在本研究中，我们发现miR-190a可在转录后沉默treRNA。miR-190a对treRNA的抑制导致间充质-上皮转化标志物发生显著变化，并损害肝癌细胞的迁移和侵袭能力。TCGA数据表明，与正常组织相比，miR-190a在肝癌组织中表达较低，尤其是在伴有血管肿瘤侵犯的患者中。我们的研究结果揭示了miR-190a-treRNA轴参与肝癌进展，并为高转移风险的肝癌患者基于lncRNA的癌症治疗提供了线索。
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