JNK的作用及p53参与生物碱红杉醇对间充质前体细胞生长潜能实现的刺激作用。
Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine.
作者信息
Zyuz'kov G N, Zhdanov V V, Udut E V, Miroshnichenko L A, Chaikovskii A V, Simanina E V, Udut V V, Stavrova L A, Polyakova T Yu, Minakova M Yu, Trifonova O Yu, Gridneva T D, Dygai A M
机构信息
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Department of Modelling Physical Processes in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2015 Nov;160(1):64-7. doi: 10.1007/s10517-015-3099-y. Epub 2015 Nov 25.
The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of realization of the growth potential of the mesenchymal precursor cells by alkaloid songorine were examined in vitro. Specific inhibitors of JNK and p53 enhanced stimulation of fibroblast colony/cluster formation and proliferative activity of mesenchymal precursor cells. Under these conditions, more pronounced effects were observed with early precursors of fibroblast CFU and in both cases were accompanied by a decrease in differentiation index of progenitor elements.
在体外研究了JNK介导的信号通路的作用以及p53转录因子参与生物碱红杉醇刺激间充质前体细胞生长潜能实现的过程。JNK和p53的特异性抑制剂增强了对成纤维细胞集落/簇形成的刺激以及间充质前体细胞的增殖活性。在这些条件下，在成纤维细胞CFU的早期前体细胞中观察到更明显的效果，并且在两种情况下均伴随着祖细胞分化指数的降低。
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