JNK的作用及p53对间充质祖细胞体外生长潜能的贡献
Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro.
作者信息
Zyuz'kov G N, Zhdanov V V, Udut E V, Miroshnichenko L A, Danilets M G, Simanina E V, Trofimova E S, Chaikovskii A V, Agafonov V I, Sherstoboev E Yu, Minakova M Yu, Burmina Ya V, Udut V V, Dygai A M
机构信息
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia,
出版信息
Bull Exp Biol Med. 2015 Jun;159(2):245-7. doi: 10.1007/s10517-015-2933-6. Epub 2015 Jun 27.
PMID:26112108
Abstract
Specific JNK and p53 inhibitors stimulated the formation of fibroblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.
摘要
特异性JNK和p53抑制剂刺激了成纤维细胞集落（CFU-F）和簇（ClFU-F）的形成，并增加了间充质祖细胞的增殖活性。未发现JNK和p53抑制剂对祖细胞分化有影响。
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