Rodriguez-Wallberg K, Turan V, Munster P, Oktay K
Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Department of Obstetrics and Gynecology, New York Medical College, Valhalla Innovation Institute for Fertility Preservation and IVF, New York.
Ann Oncol. 2016 Feb;27(2):357. doi: 10.1093/annonc/mdv554. Epub 2015 Nov 25.
Ovarian suppression via Gonadotropin releasing hormone analog (GnRHa) treatment should remain as an unproven method of fertility preservation due to lack of biological plausibility, conflicting results, and design flaws in the studies which include the lack of placebo and blinding and the utility of improper surrogates for fertility and ovarian reserve.
由于缺乏生物学合理性、结果相互矛盾以及研究存在设计缺陷,包括缺乏安慰剂对照和盲法,以及使用不恰当的生育和卵巢储备替代指标,通过促性腺激素释放激素类似物(GnRHa)治疗进行卵巢抑制仍应作为一种未经证实的生育力保存方法。