Rheumatoid factor and Fc signaling: a tale of two Cinderellas.

Signaling to lymphocytes depends not only upon the interaction of receptors with specific antigen, but also upon antigen nonspecific receptors which receive input from two classes of molecules, immunologically specific end products and lymphokines. These represent the central elements in the physiologic stimulation of immune responses to both self and foreign antigens. This review is dedicated primarily to describing the function of physiologically active receptors for end product which are central to end product feedback in normal immune responses. The emergence of autoimmunity as a pathologic process resultant from a defective end product signaling mechanism is described.