Frank M M, Lawley T J, Hamburger M I, Brown E J
Ann Intern Med. 1983 Feb;98(2):206-18. doi: 10.7326/0003-4819-98-2-218.
The reticuloendothelial system is thought to play an important role in removing immune complexes and other immunologically active substances from the circulation via interaction with specific cell-surface receptors. The function of the reticuloendothelial system in humans with autoimmune diseases was studied in vivo by measuring the rate of removal of IgG-coated, radio-labeled autologous erythrocytes. Such cells are removed by phagocytic cells of the spleen, and the process depends on the presence of an intact IgG Fc fragment. Studies in patients with active systemic lupus erythematosus show a profound defect in Fc-receptor-specific clearance that correlates with disease activity. Patients with other autoimmune diseases have defects in Fc receptor functional activity when their illness is characterized by tissue deposition of immune complexes. Normal patients with HLA-B8/DRw3, an HLA type associated with an increased incidence of autoimmune disease, also have an increased incidence of defective Fc receptor-specific functional activity, suggesting that this defect may predispose patients with this haplotype to develop manifestations of immune complex-mediated disease.
网状内皮系统被认为在通过与特定细胞表面受体相互作用从循环中清除免疫复合物和其他免疫活性物质方面发挥重要作用。通过测量包被IgG的放射性标记自体红细胞的清除率，在体内研究了自身免疫性疾病患者的网状内皮系统功能。此类细胞被脾脏的吞噬细胞清除，该过程依赖于完整IgG Fc片段的存在。对活动性系统性红斑狼疮患者的研究表明，Fc受体特异性清除存在严重缺陷，且与疾病活动相关。当其他自身免疫性疾病患者的疾病特征为免疫复合物在组织中沉积时，其Fc受体功能活性存在缺陷。具有与自身免疫性疾病发病率增加相关的HLA类型HLA - B8/DRw3的正常患者，Fc受体特异性功能活性缺陷的发生率也增加，这表明该缺陷可能使具有这种单倍型的患者易患免疫复合物介导疾病的表现。
