双膦酸盐功能化水凝胶控制生长因子的结合和释放，指导前体细胞的快速体外分化。
Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation of precursor cells in vitro.
机构信息
Science for Life Laboratory, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Unit of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, S-75121 Uppsala, Sweden.
出版信息
Biomater Sci. 2016 Feb;4(2):250-4. doi: 10.1039/c5bm00355e.
PMID:26610690
Abstract
An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.
摘要
一种原位交联透明质酸水凝胶，其通过与双膦酸盐（BP）基团结合而具有功能化，BP 基团的含量可决定骨形态发生蛋白-2（BMP-2）的释放量。固定在基质上的 BP 基团与 BMP-2 之间的高亲和力，允许在 3D 培养中对包埋的祖细胞进行定向分化。
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