Dai Kai, Geng Zhen, Zhang Wenchao, Wei Xue, Wang Jing, Nie Guangjun, Liu Changsheng
Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Natl Sci Rev. 2024 Feb 28;11(5):nwae076. doi: 10.1093/nsr/nwae076. eCollection 2024 May.
China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment, blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of 'healthy aging'.
中国人口老龄化对治疗影响生活质量的常见骨病构成挑战。由于细胞功能障碍和炎症，骨再生能力会随着年龄增长而下降，基于先进生物材料的方法为老年骨再生带来了希望。本综述综合了材料生物学原理，重点关注针对特定生物学功能以恢复组织完整性的生物材料。它涵盖了干细胞操控策略、炎症微环境调节、血管再生、骨合成代谢和分解代谢的干预以及神经调节。该综述还探讨了老年骨再生的分子和细胞机制，并提出了一个由数据库驱动的未来生物材料开发设计过程。这些见解也可能指导针对其他与年龄相关病症的治疗，有助于实现“健康老龄化”。
