Cannon Megan V, van Gilst Wiek H, de Boer Rudolf A
Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Basic Res Cardiol. 2016 Jan;111(1):3. doi: 10.1007/s00395-015-0520-7. Epub 2015 Nov 26.
Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial effects in the heart. Here, we aim to provide a conceptual framework to explain the broad mode of action of LXRs and how LXR signaling may be an important local and systemic target for the treatment of heart failure. We discuss the potential role of LXRs in systemic conditions associated with heart failure, such as hypertension, diabetes, and renal and vascular disease. Further, we expound on recent data that implicate a direct role for LXR activation in the heart, for its impact on cardiomyocyte damage and loss due to ischemia, and effects on cardiac hypertrophy, fibrosis, and myocardial metabolism. Taken together, the accumulating evidence supports the notion that LXRs may represent a novel therapeutic target for the treatment of heart failure.
肝脏X受体（LXRs）是代谢的主要调节因子，其在血管和代谢疾病中的药理学潜力已得到研究。除了它们在代谢稳态和疾病中已确立的作用外，越来越多的证据表明LXRs可能在心脏中发挥直接的有益作用。在此，我们旨在提供一个概念框架，以解释LXRs的广泛作用模式，以及LXR信号传导如何可能成为治疗心力衰竭的重要局部和全身靶点。我们讨论了LXRs在与心力衰竭相关的全身状况中的潜在作用，如高血压、糖尿病以及肾脏和血管疾病。此外，我们阐述了最近的数据，这些数据表明LXR激活在心脏中具有直接作用，对缺血引起的心肌细胞损伤和丧失有影响，并对心脏肥大、纤维化和心肌代谢有作用。综上所述，越来越多的证据支持LXRs可能代表治疗心力衰竭的一个新的治疗靶点这一观点。
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