Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease and Key Laboratory of Gastroenterology and Hepatology, Ministry of Health (Shanghai Jiao-Tong University), Shanghai, China.
J Dig Dis. 2012 Feb;13(2):69-74. doi: 10.1111/j.1751-2980.2011.00554.x.
Liver X receptors (LXRs) are members of the superfamily of metabolic nuclear receptors, which play central roles in the regulation of cholesterol absorption, efflux, transportation and excretion and many other processes correlating with lipid metabolism. LXRs can also regulate inflammation in vitro and in vivo. Accumulating evidence demonstrates that LXR are involved in the metabolism and inflammation in human diseases. Nonalcoholic fatty liver disease (NAFLD) is classically associated with lipid metabolic disorders and inflammatory responses, especially in the nonalcoholic steatohepatitis (NASH) phase. The effects of LXRs on cholesterol metabolism and inflammation make them attractive as a potential target for the treatment of NAFLD. Since the ability to synthesize triglycerides may be protective in obesity and fatty liver, the hepatic lipogenesis by LXRs should not rule out the possibility of the use of LXRs in NAFLD.
肝 X 受体（LXRs）是代谢核受体超家族的成员，在胆固醇吸收、外排、转运和排泄以及许多与脂质代谢相关的过程中发挥核心作用。LXRs 还可以调节体外和体内的炎症。越来越多的证据表明，LXR 参与了人类疾病的代谢和炎症。非酒精性脂肪性肝病（NAFLD）通常与脂质代谢紊乱和炎症反应有关，尤其是在非酒精性脂肪性肝炎（NASH）阶段。LXRs 对胆固醇代谢和炎症的影响使它们成为治疗 NAFLD 的潜在靶点。由于合成甘油三酯的能力在肥胖和脂肪肝中可能具有保护作用，因此 LXRs 的肝内脂肪生成不应排除在 NAFLD 中使用 LXRs 的可能性。
