基于水凝胶的药物输送生物传感器和传感设备。
Hydrogel-based biosensors and sensing devices for drug delivery.
机构信息
Institute for Biomaterials, Drug Delivery and Regenerative Medicine, McKetta Department of Chemical Engineering, Department of Biomedical Engineering, and Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712-1062, United States.
Institute for Biomaterials, Drug Delivery and Regenerative Medicine, McKetta Department of Chemical Engineering, Department of Biomedical Engineering, and Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712-1062, United States.
出版信息
J Control Release. 2016 Oct 28;240:142-150. doi: 10.1016/j.jconrel.2015.11.022. Epub 2015 Nov 21.
In the past 15years drug delivery devices have received added attention, not only as passive systems of drug delivery that respond to the needs of the health care provider or the patient but have an added advantage or an added characteristic of being triggered by an external process of recognition of a cause, a disease or an analyte that leads to a triggering mechanism for specific drug delivery. In this review, we will examine some of the pioneering work in this field, and speak on the use of biodegradable, environmentally-responsive hydrogels as sensing components in novel microscale devices.
在过去的 15 年中，药物输送装置受到了更多的关注，它们不仅是被动的药物输送系统，对医疗保健提供者或患者的需求做出响应，而且还具有另外一个优势或特点，即可以通过外部识别原因、疾病或分析物的过程触发，从而实现特定药物输送的触发机制。在这篇综述中，我们将检查该领域的一些开创性工作，并讨论使用可生物降解的、对环境有响应的水凝胶作为新型微尺度装置中的传感元件。
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