Hell K
F. Hoffmann-La Roche & Co. Limited, Basle, Switzerland.
Eur Surg Res. 1989;21 Suppl 1:6-13. doi: 10.1159/000129052.
Present data available on ceftriaxone (Rocephin) dealing with microbiology, pharmacokinetics (long half-life, tissue penetration ability, tissue concentration present during vulnerable period, etc.), results of clinical trials, and world-wide experience seem to be in favor of ceftriaxone as the antimicrobial of choice for single-dose antibiotic prophylaxis in abdominal and biliary surgery. Single-dose surgical prophylaxis is cost-effective, has a low rate of adverse drug events, and so far does not increase danger of resistance.
目前有关头孢曲松（罗氏芬）的微生物学、药代动力学（半衰期长、组织穿透能力、在易感染期的组织浓度等）、临床试验结果及全球经验等方面的数据，似乎都支持将头孢曲松作为腹部和胆道手术单剂量抗生素预防的首选抗菌药物。单剂量手术预防具有成本效益，药物不良事件发生率低，且迄今为止不会增加耐药风险。
