Sun Yue, Shang Dejing
School of Life Science, Liaoning Normal University, Dalian 116081, China.
School of Life Science, Liaoning Normal University, Dalian 116081, China ; Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian 116081, China.
Mediators Inflamm. 2015;2015:167572. doi: 10.1155/2015/167572. Epub 2015 Nov 3.
Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activities and specific antimicrobial mechanism. Besides broad-spectrum antibacterial activity, AMPs also have anti-inflammatory activity. The neutralization of lipopolysaccharides (LPS) plays a key role in anti-inflammatory action of AMPs. On the one hand, AMPs can readily penetrate the cell wall barrier by neutralizing LPS to remove Gram-negative bacteria that can lead to infection. On the contrary, AMPs can also inhibit the production of biological inflammatory cytokines to reduce the inflammatory response through neutralizing circulating LPS. In addition, AMPs also modulate the host immune system by chemotaxis of leukocytes, to promote immune cell proliferation, epithelialization, and angiogenesis and thus play a protective role. This review summarizes some recent researches about anti-inflammatory AMPs, with a focus on the interaction of AMPs and LPS on the past decade.
抗菌肽（AMPs）通常是小分子肽，具有广谱抗菌活性、高效性和稳定性。对于多重耐药菌株，由于其广谱抗菌活性和独特的抗菌机制，抗菌肽在新型抗生素的研发中发挥着重要作用。除了广谱抗菌活性外，抗菌肽还具有抗炎活性。脂多糖（LPS）的中和在抗菌肽的抗炎作用中起关键作用。一方面，抗菌肽可以通过中和LPS轻易穿透细胞壁屏障，清除可导致感染的革兰氏阴性菌。相反，抗菌肽还可以通过中和循环中的LPS来抑制生物炎性细胞因子的产生，从而减轻炎症反应。此外，抗菌肽还通过白细胞趋化作用调节宿主免疫系统，促进免疫细胞增殖、上皮化和血管生成，从而发挥保护作用。本综述总结了一些关于抗炎抗菌肽的最新研究，重点关注过去十年中抗菌肽与LPS的相互作用。
