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个性化医疗时代肿瘤学中的功能磁共振成像技术

Functional MR Imaging Techniques in Oncology in the Era of Personalized Medicine.

作者信息

Benz Matthias R, Vargas Hebert Alberto, Sala Evis

机构信息

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Petersgraben 4, Basel 4031, Switzerland.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

出版信息

Magn Reson Imaging Clin N Am. 2016 Feb;24(1):1-10. doi: 10.1016/j.mric.2015.08.001. Epub 2015 Sep 26.

Abstract

DW and DCE MR imaging contribute significantly to diagnosis, treatment planning, response assessment, and prognosis in personalized cancer medicine. Nevertheless, the need for further standardization of these techniques needs to be addressed. Whole-body DW MR imaging is an exciting field; however, future studies need to investigate in more depth the biologic significance of the findings depicted, their prognostic relevance, and cost-effectiveness in comparison with MDCT and PET/CT. New MR imaging probes, such as targeted or activatable contrast agents and dynamic nuclear hyperpolarization, show great promise to further improve the care of patients with cancer in the near future.

摘要

扩散加权成像(DW)和动态对比增强磁共振成像(DCE MR)在个性化癌症医学的诊断、治疗规划、疗效评估和预后判断方面发挥着重要作用。然而,这些技术进一步标准化的需求仍有待解决。全身DW磁共振成像前景广阔;不过,未来的研究需要更深入地探究所呈现结果的生物学意义、其预后相关性以及与多层螺旋CT(MDCT)和正电子发射断层显像/X线计算机体层成像(PET/CT)相比的成本效益。新型磁共振成像探针,如靶向或可激活造影剂以及动态核极化技术,有望在不久的将来进一步改善癌症患者的治疗。

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