嗜酸性肾肿瘤中的诊断生物标志物

Diagnostic Biomarkers in Eosinophilic Renal Neoplasms.

作者信息

Khor Li Yan, Tan Puay Hoon

机构信息

Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore.

Department of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore 169856, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117594, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, MD10, 4 Medical Drive, Singapore 117594, Singapore; Duke-NUS Graduate Medical School Singapore, 8 College Road, Singapore 169857, Singapore.

出版信息

Urol Clin North Am. 2016 Feb;43(1):87-94. doi: 10.1016/j.ucl.2015.08.008.

DOI:10.1016/j.ucl.2015.08.008

PMID:26614031

Abstract

Incidental small renal masses identified on imaging are increasingly investigated via needle core or fine needle aspiration biopsies with limited material provided for rendering a diagnosis. Lesions with a prominent eosinophilic or oncocytic cell presence showing morphologic overlap between well-known eosinophilic neoplasms are challenging to diagnose. We review the range of known benign and malignant eosinophilic renal neoplasms and their immunoprofiles to elucidate a useful panel of stains that may assist the pathologist in making an accurate diagnosis.

摘要

影像学检查偶然发现的小肾肿块越来越多地通过针芯活检或细针穿刺活检进行研究，用于诊断的材料有限。具有显著嗜酸性或嗜酸性细胞瘤细胞存在、在已知嗜酸性肿瘤之间表现出形态学重叠的病变诊断具有挑战性。我们回顾了已知的良性和恶性嗜酸性肾肿瘤的范围及其免疫表型，以阐明一组有用的染色剂，可能有助于病理学家做出准确诊断。