Getta Bartlomiej M, Park Jae H, Tallman Martin S
Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA.
Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA; Weill Cornell Medical College, 1305 York Avenue, New York 10021, USA.
Best Pract Res Clin Haematol. 2015 Dec;28(4):269-72. doi: 10.1016/j.beha.2015.10.015. Epub 2015 Oct 21.
This brief review highlights the sequence of therapeutic milestones and advances in our understanding of the biology of hairy cell leukemia (HCL) with a focus on recent molecular findings and how these may be applied to improve disease outcomes in the future. Targeted therapy is discussed in the context of the recently identified BRAF mutation and other genetic findings.
本简要综述重点介绍了毛细胞白血病（HCL）治疗里程碑的先后顺序以及我们对其生物学认识的进展，着重关注近期的分子研究发现以及这些发现如何应用于未来改善疾病预后。在最近发现的BRAF突变及其他遗传学发现的背景下讨论了靶向治疗。
