Mazunin I O, Levitskii S A, Patrushev M V, Kamenski P A
Immanuil Kant Baltic Federal University, Institute of Chemistry and Biology, Kaliningrad, 236038, Russia.
Biochemistry (Mosc). 2015 Nov;80(11):1418-28. doi: 10.1134/S0006297915110036.
Mitochondria possess their own genome that, despite its small size, is critically important for their functioning, as it encodes several dozens of RNAs and proteins. All biochemical processes typical for bacterial and nuclear DNA are described in mitochondrial matrix: replication, repair, recombination, and transcription. Commonly, their mechanisms are similar to those found in bacteria, but they are characterized by several unique features. In this review, we provide an overall description of mitochondrial matrix processes paying special attention to the typical features of such mechanisms.
线粒体拥有自己的基因组,尽管其规模较小,但对其功能至关重要,因为它编码几十种RNA和蛋白质。线粒体基质中存在细菌和核DNA所特有的所有生化过程:复制、修复、重组和转录。通常,它们的机制与细菌中的相似,但具有一些独特的特征。在这篇综述中,我们对线粒体基质过程进行了全面描述,并特别关注这些机制的典型特征。