Guénette Line, Breton Marie-Claude, Guillaumie Laurence, Lauzier Sophie, Grégoire Jean-Pierre, Moisan Jocelyne
Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
Faculty of Pharmacy, Laval University, Quebec City, QC, Canada; Chair on Adherence to Treatments, Population Health and Optimal Health Practices Research Unit, CHU de Québec Research Center, Quebec City, QC, Canada.
J Diabetes Complications. 2016 Mar;30(2):335-42. doi: 10.1016/j.jdiacomp.2015.10.016. Epub 2015 Oct 24.
To discern psychosocial factors of non-insulin antidiabetes drug (NIAD) adherence.
A cross-sectional study based on the theory of planned behavior (TPB). Adults with type 2 diabetes (T2D) who were members of Diabète Québec, a provincial association of persons with diabetes, and were prescribed at least one NIAD were invited to complete a web-based questionnaire. We measured variables ascertaining TPB constructs and other factors potentially associated with NIAD adherence (e.g., habit, social support, and mental health). NIAD adherence was assessed using the 8-item Morisky Medication Adherence Scale. Factors were identified using a multivariate logistic regression model.
In our study, 901 participants (373 women; 515 retired; mean age: 62.7 years) with T2D for a mean of 10 years, completed the questionnaire. Participants exhibited a high intention to adhere to their NIAD treatment (mean score=5.8/6), positive attitudes toward adherence (mean score=5.5/6), and elevated perceived behavioral control in taking their medication (mean score=5.7/6). Only 405 (45%) participants reported high adherence (score=8/8). Perceived behavioral control, habit, older age, no perceived side effects, a longer period since T2D diagnosis and a lower number of NIAD daily doses were significantly associated with adherence (p<0.05).
We identified several factors that may be modified for NIAD adherence and thereby provided insight into future adherence-enhancing intervention targets.
识别非胰岛素抗糖尿病药物（NIAD）依从性的社会心理因素。
基于计划行为理论（TPB）的横断面研究。邀请魁北克糖尿病协会（一个省级糖尿病患者协会）的成年2型糖尿病（T2D）患者，他们被开具了至少一种NIAD药物，并被邀请完成一份基于网络的问卷。我们测量了确定TPB结构以及其他可能与NIAD依从性相关的因素（如习惯、社会支持和心理健康）的变量。使用8项Morisky药物依从性量表评估NIAD依从性。使用多变量逻辑回归模型识别因素。
在我们的研究中，901名平均患有T2D 10年的参与者（373名女性；515名退休人员；平均年龄：62.7岁）完成了问卷。参与者表现出较高的坚持服用NIAD治疗的意愿（平均得分=5.8/6）、对依从性的积极态度（平均得分=5.5/6）以及在服药方面较高的感知行为控制（平均得分=5.7/6）。只有405名（45%）参与者报告高依从性（得分=8/8）。感知行为控制、习惯、年龄较大、未感知到副作用、T2D诊断后的时间较长以及NIAD每日剂量较少与依从性显著相关（p<0.05）。
我们确定了几个可能针对NIAD依从性进行调整的因素，从而为未来增强依从性的干预目标提供了见解。
