Frumin H, Kerin N Z, Rubenfire M
Department of Medicine, Sinai Hospital of Detroit, Michigan 48235-2099.
J Clin Pharmacol. 1989 May;29(5):387-94. doi: 10.1002/j.1552-4604.1989.tb03350.x.
Although many classification schemes for antiarrhythmic drugs have been proposed, the system introduced by Vaughan Williams and later modified by Harrison has been widely accepted. This classification system is comprised of four categories. Class I agents block sodium channels. Class II agents are Beta blockers. Class III agents prolong the cardiac action potential. Class IV agents are calcium channel blockers. This classification scheme, based largely on clinical observation continues to be useful almost two decades after its introduction. The electrophysiologic bases, strengths and weaknesses of this system are discussed.
虽然已经提出了许多抗心律失常药物的分类方案，但由沃恩·威廉姆斯提出并随后由哈里森修改的系统已被广泛接受。该分类系统由四类组成。I类药物阻断钠通道。II类药物是β受体阻滞剂。III类药物延长心脏动作电位。IV类药物是钙通道阻滞剂。这个主要基于临床观察的分类方案在引入近二十年后仍然有用。本文讨论了该系统的电生理基础、优点和缺点。
