Muraoka H
Department of Orthopedic Surgery, Hiroshima University School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1989 Apr;63(4):320-34.
An experimental study was conducted to determine how age affects growth capacity and development of a growth zone in cases of free autogenous bone transplantation. Using immature Japanese white rabbits, the second metatarsus was removed together with the epiphyseal cartilage and a small portion of the surrounding soft tissues, and was implanted under the skin of the foreleg. Animals were divided into a 1-week-old group, a 2-week-old group and a 4-week-old group, and these groups were studied comparatively by periodic radiography, histopathology, and microangiography. In terms of bone length, a notable growth capacity was observed in the 1-week-old group, but was reduced in the 2-week-old group, with no growth being seen in the 4-week-old group. The width of the bone was reduced in all groups. In clinical applications of this technique, it is preferable to operate as soon as possible after birth. Moreover, transplantation should be carried out before the appearance of the epiphyseal nucleus of the donor for best bone growth.
进行了一项实验研究，以确定在自体骨移植情况下年龄如何影响生长区的生长能力和发育。使用未成熟的日本白兔，切除第二跖骨及其骨骺软骨和一小部分周围软组织，并将其植入前肢皮下。将动物分为1周龄组、2周龄组和4周龄组，并通过定期X线摄影、组织病理学和微血管造影对这些组进行比较研究。在骨长度方面，1周龄组观察到显著的生长能力，但在2周龄组中生长能力降低，4周龄组未见生长。所有组的骨宽度均减小。在该技术的临床应用中，最好在出生后尽快进行手术。此外，为了实现最佳的骨生长，移植应在供体骨骺核出现之前进行。
