Compton Michael T, Goulding Sandra M, Ramsay Claire E, Addington Jean, Corcoran Cheryl, Walker Elaine F
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia, U.S.A.
Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Ontario; and Department of Psychiatry, University of Calgary, Alberta, Canada.
Clin Neuropsychiatry. 2008 Dec;5(6):263-272.
Clinicians and researchers in Canada and the United States have established a number of early intervention programs and research sites on the early course of psychosis and the prodromal period that commonly precedes psychotic disorders. In Canada, early detection and treatment programs for psychosis have been established in many areas of the country, and typically serve specific catchment areas. Canadian research on early psychosis is often built on to these clinical sites, and covers a broad array of topics including interventions during the prodromal stage of the illness, treatment-seeking behaviors, and development of optimal pharmacological and psychosocial treatment approaches for early psychosis. In the United States, clinical programs for early intervention in psychosis are often located at academic programs with ongoing research on the early course of psychotic disorders. Researchers from sites across the United States offer a plethora of information, including neuroimaging studies, research on treatment response, and the development of standardized rating scales and research instruments. Researchers from sites in both countries have formed a consortium to launch the North American Prodrome Longitudinal Study, a multi-site collaboration to gain a better understanding of the prodromal period of the illness and prediction of conversion from the prodrome to psychosis.
加拿大和美国的临床医生及研究人员已在精神病早期病程以及通常先于精神障碍出现的前驱期方面设立了多个早期干预项目和研究地点。在加拿大，该国许多地区都已建立了精神病早期检测与治疗项目，且通常服务于特定的集水区。加拿大对早期精神病的研究往往以这些临床地点为基础，涵盖广泛的主题，包括疾病前驱期的干预措施、寻求治疗行为，以及早期精神病最佳药物和心理社会治疗方法的开发。在美国，精神病早期干预临床项目通常位于对精神病性障碍早期病程进行持续研究的学术项目中。来自美国各地研究地点的研究人员提供了大量信息，包括神经影像学研究、治疗反应研究，以及标准化评定量表和研究工具的开发。来自两国研究地点的研究人员组成了一个联盟，发起了北美前驱期纵向研究，这是一项多地点合作项目，旨在更好地了解疾病的前驱期以及从前驱期向精神病转变的预测情况。
