MUM-1表达可将伴有霍奇金淋巴瘤样细胞的血管免疫母细胞性T细胞淋巴瘤与经典型霍奇金淋巴瘤区分开来。
MUM-1 expression differentiates AITL with HRS-like cells from cHL.
作者信息
Huang Wenyong, Xie Jianlan, Xu Xiao, Gao Xue, Xie Ping, Zhou Xiaoge
机构信息
Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China ; Department of Pathology, The First Affiliated Hospital of Jiujiang University Jiujiang, China.
Department of Pathology, Beijing Friendship Hospital of Capital Medical University Beijing 100050, China.
出版信息
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11372-8. eCollection 2015.
MUM1 is a member of the interferon regulatory factor family of transcription factors. It is normally expressed in plasma cells, late B cells, and activated T cells, and has been described in several B-cell malignancies and some T-cell neoplasms. The aim of our study was to evaluate the role of MUM-1/IRF4 protein in differentiating angioimmunoblastic T cell lymphoma (AITL) with Hodgkin/Reed-Sternberg (HRS)-like cells from cHL. We identified 12 cases of AITL with HRS-like cells and 24 cases of cHL from March 2013 to November 2014. IHC for MUM-1/IRF4 protein was performed on the tissue of these cases and some relevant positive and negative controls. MUM-1 was expressed in HRS-like cells and some neoplastic T-cells in AITL with HRS-like cells (12/12, 100%) and formed the rosettes around the HRS-like cells (12/12, 100%), expressed in HRS cells in classic Hodgkin Lymphoma (cHL) (24/24, 100%) and just one case formed rosettes around the HRS cells (1/24, 4.2%). Based on the results, MUM-1 could be a useful marker for the differential diagnosis between AITL with HRS-like cells and cHL.
MUM1是转录因子干扰素调节因子家族的成员。它通常在浆细胞、晚期B细胞和活化T细胞中表达，并且在几种B细胞恶性肿瘤和一些T细胞肿瘤中也有报道。我们研究的目的是评估MUM-1/IRF4蛋白在鉴别伴有霍奇金/里德-斯腾伯格（HRS）样细胞的血管免疫母细胞性T细胞淋巴瘤（AITL）与经典型霍奇金淋巴瘤（cHL）中的作用。我们在2013年3月至2014年11月期间鉴定出12例伴有HRS样细胞的AITL病例和24例cHL病例。对这些病例的组织以及一些相关的阳性和阴性对照进行了MUM-1/IRF4蛋白的免疫组化检测。MUM-1在伴有HRS样细胞的AITL的HRS样细胞和一些肿瘤性T细胞中表达（12/12，100%），并在HRS样细胞周围形成玫瑰花结（12/12，100%）；在经典型霍奇金淋巴瘤（cHL）的HRS细胞中表达（24/24，100%），但仅1例在HRS细胞周围形成玫瑰花结（1/24，4.2%）。基于这些结果，MUM-1可能是鉴别伴有HRS样细胞的AITL与cHL的有用标志物。
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