目的分析聚左旋乳酸注射液在不同情况下的疗效。

Objective Analysis of Poly-L-Lactic Acid Injection Efficacy in Different Settings.

作者信息

Byun Sang-Young, Seo Koo-Il, Shin Jung-Won, Kwon Soon-Hyo, Park Mi-Sook, Lee Joshua, Park Kyoung-Chan, Na Jung-Im, Huh Chang-Hun

机构信息

*Department of Dermatology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea; †Modelo Clinic, Seoul, Korea; ‡College of Medicine, Emory University, Atlanta, Georgia.

出版信息

Dermatol Surg. 2015 Dec;41 Suppl 1:S314-20. doi: 10.1097/DSS.0000000000000552.

DOI:10.1097/DSS.0000000000000552

PMID:26618458

Abstract

BACKGROUND

Poly-L-lactic acid (PLLA) filler is known to have continuous volume effect.

OBJECTIVE

The objective of this study is to analyze objective volume effect of PLLA in different settings of injection schedule on the cheek.

METHODS

A split-face, evaluator-blind randomized study in 24 volunteers was conducted. One side was injected 3 times with 4 cc dose and the other side was injected 2 times with 6 cc dose per visit. Facial volume loss scale (FVLS) and Vectra were evaluated.

RESULTS

Measured average FVLS showed statistically significant improvement both in 3 and 2 times injection sides and maintained efficacy until 12 months. Vectra showed volume difference (cc) between before and after injection. In 3 times injection side, it was increased 2.12 (after 1 month) to 3.17 (after 12 months). In 2 times injection side, it was increased 2.26 (after 1 month) to 3.19 (after 12 months). Gradual volume improvement over 12 months was statistically significant in both sides. There was no statistically significant difference between 3 and 2 times injection in FVLS and Vectra. There was no severe adverse event.

CONCLUSION

Poly-L-lactic acid has continuous volume effect and there was no significant difference by injection times at the same total injection volume.

摘要

背景

聚左旋乳酸（PLLA）填充剂具有持续的容积效应。

目的

本研究旨在分析PLLA在不同注射方案下对面颊的客观容积效应。

方法

对24名志愿者进行了一项半脸、评估者盲法随机研究。一侧每次注射4 cc，共注射3次；另一侧每次注射6 cc，共注射2次。评估面部容积丢失量表（FVLS）和Vectra。

结果

测量的平均FVLS显示，3次注射侧和2次注射侧均有统计学意义的改善，且疗效维持至12个月。Vectra显示注射前后的容积差异（cc）。在3次注射侧，容积从注射后1个月的增加2.12增加到注射后12个月的3.17。在2次注射侧，容积从注射后1个月的增加2.26增加到注射后12个月的3.19。两侧在12个月内的容积逐渐改善具有统计学意义。在FVLS和Vectra方面，3次注射和2次注射之间没有统计学意义的差异。没有严重不良事件。