Bahouth Zaher, Halachmi Sarel, Moskovitz Boaz, Nativ Ofer
a Department of Urology, Bnai-Zion Medical Center, Faculty of Medicine , Technion- Institute of Technology , Haifa , Israel.
Expert Rev Anticancer Ther. 2016;16(2):189-98. doi: 10.1586/14737140.2016.1126515. Epub 2015 Dec 19.
Non-muscle invasive bladder cancer (NMIBC) has a high tendency for recurrence and progression. Currently, all known intravesical agents are associated with adverse effects (AEs) and limited efficacy. The combination of hyperthermia (HT) with intravesical Mitomycin C (MMC) chemotherapy has been shown to improve outcomes. The added efficacy of HT to MMC was first shown in preclinical studies. The reports on patients with NMIBC have indicated that the treatment is safe and well tolerated. Several clinical studies reported the efficacy of radiofrequency-induced chemotherapy effect (RITE) in the treatment of patients with NMIBC. This modality was shown to be superior to MMC alone. RITE was effective also in patients with high-risk NMIBC, including those who failed Bacillus Calmette-Guérin (BCG). This study provides an updated review of literature regarding the use of RITE in patients with NMIBC.
非肌层浸润性膀胱癌（NMIBC）具有较高的复发和进展倾向。目前，所有已知的膀胱内用药都伴有不良反应（AE）且疗效有限。热疗（HT）与膀胱内丝裂霉素C（MMC）化疗联合应用已显示可改善治疗效果。HT对MMC的增效作用首先在临床前研究中得到证实。关于NMIBC患者的报告表明该治疗安全且耐受性良好。多项临床研究报告了射频诱导化疗效应（RITE）在治疗NMIBC患者中的疗效。这种治疗方式被证明优于单纯使用MMC。RITE对高危NMIBC患者也有效，包括那些卡介苗（BCG）治疗失败的患者。本研究提供了关于RITE在NMIBC患者中应用的文献最新综述。
