Soares Juliana Carlota Kramer, Perfetto Juliano Genaro, Antonio Bruno Brito, Oliveira Maria Gabriela Menezes
Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP).
Behav Neurosci. 2016 Feb;130(1):29-35. doi: 10.1037/bne0000113. Epub 2015 Nov 30.
Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.
广泛的研究表明，中枢胆碱能系统参与了涉及条件性恐惧反应任务的获得和巩固，例如在情境恐惧条件反射（CFC）、音调恐惧条件反射（TFC）和抑制性回避（IA）中观察到的那些反应。然而，关于该系统在记忆检索过程中的作用的数据很少。因此，本研究旨在比较给予M1拮抗剂对这些任务中检索的影响。对于每个行为程序，对雄性Wistar大鼠组进行训练。24小时后，在测试前30分钟，它们接受不同剂量的双环维林（16、32或64毫克/千克，腹腔注射）或生理盐水治疗。结果表明，16和32毫克/千克剂量的双环维林损害了CFC，但不影响IA表现。此外，只有64毫克/千克损害了TFC。这些数据表明，M1毒蕈碱受体有助于CFC和TFC中的记忆检索，但对IA中的检索不是必需的。
