Meghrajani Chandra F, Co Henri S, Arcillas Jon G, Maaño Clarita C, Cupino Nonette A
a Section of Dermatology, Department of Medicine , Philippine General Hospital , Manila , Philippines.
b Section of Radiation Oncology, Department of Radiology , Philippine General Hospital , Manila , Philippines.
Expert Rev Clin Pharmacol. 2016;9(3):483-91. doi: 10.1586/17512433.2016.1126506. Epub 2016 Jan 9.
To determine whether the application of 1% hydrocortisone cream during radiation therapy can prevent the occurrence of moist desquamation.
Fifty adult female breast carcinoma patients were randomized after modified radical mastectomy and chemotherapy to receive prophylactic placebo cream (n = 27) or 1% hydrocortisone cream (n = 23) during radiation therapy. The patients, caregiver and assessor were all blinded to the treatment received. Occurrence of moist desquamation, severity of acute radiation dermatitis (ARD) and hyperpigmentation were evaluated weekly until the end of radiotherapy.
RESULTS & CONCLUSION: Five patients in each group developed moist desquamation; however, its extent and severity were milder in the steroid group. Mean ARD scores were also lower in the steroid group (0.713 vs. 0.874, p = 0.024). A lower incidence of Grades 1 and 2 radiation dermatitis was also noted in the steroid group at weeks 2 and 4, respectively, indicating prophylactic use of steroids delayed the onset of radiodermatitis.
确定在放射治疗期间应用1%氢化可的松乳膏是否可预防湿性脱屑的发生。
50例成年女性乳腺癌患者在改良根治性乳房切除术和化疗后被随机分组，在放射治疗期间接受预防性安慰剂乳膏（n = 27）或1%氢化可的松乳膏（n = 23）。患者、护理人员和评估者均对所接受的治疗不知情。每周评估湿性脱屑的发生情况、急性放射性皮炎（ARD）的严重程度和色素沉着情况，直至放疗结束。
每组各有5例患者发生湿性脱屑；然而，类固醇组的脱屑范围和严重程度较轻。类固醇组的平均ARD评分也较低（0.713对0.874，p = 0.024）。在第2周和第4周时，类固醇组1级和2级放射性皮炎的发生率也较低，表明预防性使用类固醇可延迟放射性皮炎的发生。
