Boutas Ioannis, Pergialiotis Vasilios, Salakos Nicolaos, Agrogiannis George, Konstantopoulos Panagiotis, Korou Laskarina-Maria, Kalampokas Theodoros, Gregoriou Odysseas, Creatsas George, Perrea Despina
Second Department of Obstetrics and Gynecology, University of Athens, Vas. Sofias 76, Athens, 11528, Greece.
Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma 15B, Athens, 11527, Greece.
Sci Rep. 2015 Dec 1;5:17493. doi: 10.1038/srep17493.
Anastrazole and Letrozole are used as endocrine therapy for breast cancer patients. Previous studies suggested a possible association with metabolic and liver adverse effects. Their results are conflicting. Fifty-five 4-week-old female Wistar rats were allocated in 4 groups 1) ovariectomy control (OC), 2) ovariectomy-Anastrazole (OA) 3) ovariectomy -Letrozole (OL), 4) control. Serum glucose, cholesterol, triglycerides, HDL-c and LDL-c were measured at baseline, 2 and 4 months. At the end, the animals' liver were dissected for pathology. At 4 months, total cholesterol differed among the OC and OL groups (p = 0.15) and the control and OL groups (p = 0.12). LDL-C differed between the control and OC groups (p = 0.015) as well as between the control and OA (p =0 .015) and OL groups (p = 0.002). OC group triglycerides, differed from those of the OL group (p =0 .002) and the control group (p = 0.007). The OA also significantly differed from the OL (p = 0.50). Liver pathology analysis revealed differences among groups with favored mild steatosis and ballooning. Anastrazole and Letrozole seem to negatively influence the lipid profile in our experimental model. This information should be taken in caution by medical oncologists when addressing patients with altered lipid metabolism.
阿那曲唑和来曲唑被用作乳腺癌患者的内分泌治疗药物。先前的研究表明它们可能与代谢和肝脏不良反应有关。但这些研究结果相互矛盾。将55只4周龄的雌性Wistar大鼠分为4组：1）卵巢切除对照组（OC）；2）卵巢切除-阿那曲唑组（OA）；3）卵巢切除-来曲唑组（OL）；4）对照组。在基线、2个月和4个月时测量血清葡萄糖、胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-c）和低密度脂蛋白胆固醇（LDL-c）。实验结束时，解剖动物的肝脏进行病理学检查。在4个月时，OC组和OL组之间的总胆固醇存在差异（p = 0.15），对照组和OL组之间也存在差异（p = 0.12）。对照组和OC组之间的LDL-C存在差异（p = 0.015），对照组与OA组（p = 0.015）和OL组（p = 0.002）之间也存在差异。OC组的甘油三酯与OL组（p = 0.002）和对照组（p = 0.007）不同。OA组与OL组之间也存在显著差异（p = 0.50）。肝脏病理学分析显示各组之间存在差异，倾向于轻度脂肪变性和气球样变。在我们的实验模型中，阿那曲唑和来曲唑似乎对脂质谱有负面影响。肿瘤内科医生在治疗脂质代谢改变的患者时应谨慎考虑这些信息。
