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肝细胞癌的钇-90放射性栓塞——性能、技术进展及未来概念

Yttrium-90 Radioembolization of Hepatocellular Carcinoma-Performance, Technical Advances, and Future Concepts.

作者信息

Molvar Christopher, Lewandowski Robert

机构信息

Section of Vascular and Interventional Radiology, Department of Radiology, Loyola University Medical Center, Maywood, Illinois.

Division of Interventional Oncology, Section of Interventional Radiology, Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

出版信息

Semin Intervent Radiol. 2015 Dec;32(4):388-97. doi: 10.1055/s-0035-1564704.

DOI:10.1055/s-0035-1564704
PMID:26622103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4640917/
Abstract

Hepatocellular carcinoma (HCC) is a lethal tumor, claiming over half a million lives per year. Treatment of HCC is commonly performed without curative intent, and palliative options dominate, including catheter-based therapies, namely, transarterial chemoembolization and yttrium-90 ((90)Y) radioembolization. This review will showcase the performance of (90)Y radioembolization for the treatment of HCC, focusing on recent seminal data and technical advances. In particular, novel radioembolization treatment concepts are discussed and compared with conventional HCC therapy.

摘要

肝细胞癌(HCC)是一种致命性肿瘤,每年导致超过50万人死亡。HCC的治疗通常不以治愈为目的,姑息治疗方法占主导,包括基于导管的治疗,即经动脉化疗栓塞术和钇-90(90Y)放射性栓塞术。本综述将展示90Y放射性栓塞术在治疗HCC方面的表现,重点关注近期的重要数据和技术进展。特别是,将讨论新型放射性栓塞治疗概念并与传统HCC治疗方法进行比较。

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本文引用的文献

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Microsphere localization and dose quantification using positron emission tomography/CT following hepatic intraarterial radioembolization with yttrium-90 in patients with advanced hepatocellular carcinoma.使用正电子发射断层扫描/计算机断层扫描对晚期肝细胞癌患者进行钇-90肝动脉内放射性栓塞后微球定位及剂量定量分析
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2
Combination of intra-arterial therapies and sorafenib: is there a clinical benefit?动脉内治疗与索拉非尼联合应用:是否具有临床获益?
Radiol Med. 2014 Jul;119(7):476-82. doi: 10.1007/s11547-014-0413-0. Epub 2014 Jun 4.
3
Superselective yttrium-90 radioembolization for hepatocellular carcinoma yields high response rates with minimal toxicity.用于肝细胞癌的超选择性钇-90放射性栓塞术可产生高缓解率且毒性极小。
J Vasc Interv Radiol. 2014 Jul;25(7):1067-73. doi: 10.1016/j.jvir.2014.03.030. Epub 2014 May 14.
4
Unresectable solitary hepatocellular carcinoma not amenable to radiofrequency ablation: multicenter radiology-pathology correlation and survival of radiation segmentectomy.不可切除的单发肝细胞癌不适合射频消融:多中心放射科-病理相关性和放射段切除术的生存。
Hepatology. 2014 Jul;60(1):192-201. doi: 10.1002/hep.27057. Epub 2014 May 27.
5
Portal vein embolization before right hepatectomy or extended right hepatectomy using sodium tetradecyl sulfate foam: technique and initial results.使用十四烷基硫酸钠泡沫在右肝切除术或扩大右肝切除术前行门静脉栓塞:技术及初步结果
J Vasc Interv Radiol. 2014 Jul;25(7):1045-53. doi: 10.1016/j.jvir.2014.01.034. Epub 2014 Mar 19.
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