Synthesis of 5-Aminoimidazole-4-Carboxamide Riboside (AICAR) and Its Derivatives Using Inosine as Starting Material.
作者信息
D'Errico Stefano, Oliviero Giorgia, Borbone Nicola, Piccialli Vincenzo, Piccialli Gennaro
机构信息
Dipartimento di Farmacia, Università degli Studi di Napoli 'Federico II', Napoli, Italy.
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli 'Federico II', Napoli, Italy.
出版信息
Curr Protoc Nucleic Acid Chem. 2015 Dec 1;63:1.35.1-1.35.24. doi: 10.1002/0471142700.nc0135s63.
This unit contains four basic protocols describing the synthesis of 5-aminoimidazole-4-carboxamide riboside (AICAR), 5-aminoimidazole-4-carboxamide riboside (ZPM), their 4-N functionalized derivatives, and two sugar-modified analogs of AICAR. The first and second basic protocols reveal the importance of solid-phase synthesis to obtain novel AICAR and ZMP imidazole-modified analogs in a short time, whereas the third and fourth basic protocols allow for the rapid preparation of 5'-F-AICAR and D-ribityl AICA.
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