Breatnach C R, Flanagan F, James A, Corcoran J D, Franklin O, El-Khuffash A
Ir Med J. 2015 Oct;108(9):275-8.
There is currently insufficient evidence to create a standardised protocol for the use and weaning of inhaled nitric oxide (iNO). We aimed to determine our application of iNO in this patient cohort. We performed a retrospective chart review on patients receiving iNO therapy for persistent pulmonary hypertension of the newborn (PPHN) from a single tertiary neonatal centre in 2014. The data was entered into the European Inhaled Nitric Oxide Registry. Thirty two babies were treated with iNO during this period, 9 of which were less than 32 weeks gestation. The median time to initiation of iNO treatment was 4-5 hours and the median duration of treatment was 74 hours for term and 66 hours for preterm infants. We recommend that further use of the European Inhaled Nitric Oxide Registry across more neonatal units in the Republic of Ireland could lead to the development of national guidelines on iNO use and weaning in this cohort.
目前尚无足够证据制定吸入一氧化氮（iNO）使用及撤机的标准化方案。我们旨在确定iNO在该患者队列中的应用情况。我们对2014年来自单一三级新生儿中心接受iNO治疗新生儿持续性肺动脉高压（PPHN）的患者进行了回顾性病历审查。数据录入欧洲吸入一氧化氮登记处。在此期间，32例婴儿接受了iNO治疗，其中9例孕周小于32周。足月婴儿开始iNO治疗的中位时间为4 - 5小时，治疗中位持续时间为74小时，早产儿为66小时。我们建议，爱尔兰共和国更多新生儿单位进一步使用欧洲吸入一氧化氮登记处的数据，可能会促成该队列中iNO使用及撤机的国家指南的制定。
