Haller Hermann, Bertram Anna, Nadrowitz Felix, Menne Jan
Department of Nephrology and Hypertension, Medizinische Hochschule Hannover, Hannover, Germany.
Curr Opin Nephrol Hypertens. 2016 Jan;25(1):42-9. doi: 10.1097/MNH.0000000000000186.
Recently, initial studies have been carried out in patients using monocyte chemoattractant protein-1 (MCP-1) inhibitors. This review summarizes the known function of MCP-1 in regulating monocytes during inflammation and its role in inflammatory disease of the kidney.
MCP-1 is one of the first chemokines described and plays an important role in renal inflammatory disease. The function of MCP-1 has been investigated and analyzed in both animal models of renal disease and renal patients. MCP-1 mediates firstly the release of monocytes from the bone marrow, and then generates a gradient in the endothelial glycocalyx to direct monocytes to sites of inflammation, thereby alleviating the migration of blood leukocytes into the inflamed tissue. In addition, MCP-1 has direct signaling effects in monocytes and influences migration, proliferation, and differentiation of leukocytes. Blockade of MCP-1 in several models of renal disease has ameliorated the disease, suggesting that inhibition of MCP-1 is a promising and valid strategy to treat patients with renal inflammatory disease.
Understanding the role of MCP-1 in monocyte homeostasis and the implications of MCP-1 inhibition in renal disease will help in designing better diagnostic and therapeutic strategies in patients with inflammatory renal disease.
最近，已对使用单核细胞趋化蛋白-1（MCP-1）抑制剂的患者开展了初步研究。本综述总结了MCP-1在炎症过程中调节单核细胞的已知功能及其在肾脏炎性疾病中的作用。
MCP-1是最早被描述的趋化因子之一，在肾脏炎性疾病中起重要作用。已在肾脏疾病动物模型和肾病患者中对MCP-1的功能进行了研究和分析。MCP-1首先介导单核细胞从骨髓中释放，然后在内皮糖萼中形成梯度，将单核细胞导向炎症部位，从而减轻血液白细胞向炎症组织的迁移。此外，MCP-1在单核细胞中具有直接信号作用，并影响白细胞的迁移、增殖和分化。在几种肾脏疾病模型中阻断MCP-1可改善病情，这表明抑制MCP-1是治疗肾脏炎性疾病患者的一种有前景且有效的策略。
了解MCP-1在单核细胞稳态中的作用以及MCP-1抑制在肾脏疾病中的意义，将有助于为炎性肾脏疾病患者设计更好的诊断和治疗策略。
