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肥胖症的终身病因:亚洲国家的生态学和遗传学要点。

Etiology of Obesity Over the Life Span: Ecological and Genetic Highlights from Asian Countries.

机构信息

Nutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Abdul Aziz, 50300, Kuala Lumpur, Malaysia.

UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Jalan Ya'acob Latiff, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.

出版信息

Curr Obes Rep. 2014 Mar;3(1):16-37. doi: 10.1007/s13679-013-0088-1.

Abstract

Obesity is a worldwide pandemic, and the prevalence rate has doubled since the 1980s. Asian countries are also experiencing the global epidemic of obesity with its related health consequences. The prevalence of overweight and obesity are increasing at an alarming rate across all age groups in Asia. These increases are mainly attributed to rapid economic growth, which leads to socio-economic, nutrition and lifestyle transitions, resulting in a positive energy balance. In addition, fat mass and obesity-associated gene variants, copy number variants in chromosomes and epigenetic modifications have shown positive associations with the risk of obesity among Asians. In this review highlights of prevalence and related ecological and genetic factors that could influence the rapid rise in obesity among Asian populations are discussed.

摘要

肥胖是一种全球性的流行疾病,自 20 世纪 80 年代以来,其发病率已经翻了一番。亚洲国家也正在经历肥胖的全球流行及其相关的健康后果。超重和肥胖的患病率在亚洲所有年龄段都以惊人的速度增长。这些增长主要归因于经济的快速增长,这导致了社会经济、营养和生活方式的转变,从而导致了能量的正平衡。此外,脂肪量和肥胖相关基因变异、染色体拷贝数变异和表观遗传修饰与亚洲人肥胖的风险呈正相关。在这篇综述中,重点讨论了可能影响亚洲人群肥胖率快速上升的流行率和相关生态及遗传因素。

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