全球组蛋白翻译后修饰与癌症：用于诊断、预后和治疗的生物标志物？
Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?
作者信息
Khan Shafqat Ali, Reddy Divya, Gupta Sanjay
机构信息
Shafqat Ali Khan, Divya Reddy, Sanjay Gupta, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
出版信息
World J Biol Chem. 2015 Nov 26;6(4):333-45. doi: 10.4331/wjbc.v6.i4.333.
Abstract
Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanisms such as DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular, covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further, histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review, we will explore and discuss how histone modifications are involved in cancer diagnosis, prognosis and treatment.
摘要
表观遗传景观的整体改变如今被视为癌症的一个标志。诸如DNA甲基化、组蛋白修饰、核小体定位和非编码RNA等表观遗传机制已被证明与癌症密切相关。特别是，组蛋白的共价翻译后修饰在染色质重塑进而在基因表达调控中发挥重要作用。此外，组蛋白修饰还与癌症发生的不同方面相关，并已对其在癌症患者更好管理中的作用进行了研究。在本综述中，我们将探讨并讨论组蛋白修饰如何参与癌症的诊断、预后和治疗。
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