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Cons: should a medically inoperable patient with a T2N0M0 non-small cell lung cancer central in the lung hilus be treated using stereotactic body radiotherapy?缺点：对于一名患有肺门中央型T2N0M0非小细胞肺癌且医学上无法进行手术的患者，是否应采用立体定向体部放疗进行治疗？
Transl Lung Cancer Res. 2015 Oct;4(5):623-6. doi: 10.3978/j.issn.2218-6751.2015.08.07.
2
Pros: should a medically inoperable patient with a T2N0M0 non-small cell lung cancer central in the lung hilus be treated using stereotactic body radiotherapy?优点：对于一名患有肺门中心型T2N0M0非小细胞肺癌且医学上无法手术的患者，是否应采用立体定向体部放疗进行治疗？
Transl Lung Cancer Res. 2015 Oct;4(5):619-22. doi: 10.3978/j.issn.2218-6751.2015.08.08.
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[An analysis of 20 consecutive patients treated with stereotactic body radiotherapy on Novalis Tx(®) for stage I non-small-cell lung cancer].[对20例接受Novalis Tx(®)立体定向体部放射治疗的I期非小细胞肺癌患者的分析]
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Stereotactic body radiotherapy and treatment at a high volume facility is associated with improved survival in patients with inoperable stage I non-small cell lung cancer.立体定向体部放疗和在高容量机构治疗与不能手术的 I 期非小细胞肺癌患者的生存改善相关。
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Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.立体定向体部放疗治疗医学上无法手术的Ⅰ期非小细胞肺癌患者的前瞻性Ⅱ期试验结果
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Lung Cancer. 2016 Jul;97:51-8. doi: 10.1016/j.lungcan.2016.04.012. Epub 2016 Apr 26.
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Stereotactic ablative radiotherapy for medically inoperable early stage lung cancer: early outcomes.立体定向消融放疗治疗无法手术的早期肺癌：早期结果。
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Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer.I期肺癌健康患者的肺叶切除术与立体定向体部放疗对比
J Thorac Cardiovasc Surg. 2016 Jul;152(1):44-54.e9. doi: 10.1016/j.jtcvs.2016.03.060. Epub 2016 Apr 7.

本文引用的文献

1
SPACE - A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC.SPACE - 立体定向体部放疗与传统分割放疗治疗医学上无法手术的Ⅰ期非小细胞肺癌的随机研究
Radiother Oncol. 2016 Oct;121(1):1-8. doi: 10.1016/j.radonc.2016.08.015. Epub 2016 Sep 3.
2
LungTech, an EORTC Phase II trial of stereotactic body radiotherapy for centrally located lung tumours: a clinical perspective.LungTech，一项欧洲癌症研究与治疗组织（EORTC）针对中央型肺肿瘤的立体定向体部放疗II期试验：临床视角。
Br J Radiol. 2015 Jul;88(1051):20150036. doi: 10.1259/bjr.20150036. Epub 2015 Apr 15.
3
Local control and toxicity in a large cohort of central lung tumors treated with stereotactic body radiation therapy.立体定向体部放疗治疗的一大组中央型肺肿瘤患者的局部控制情况及毒性反应
Int J Radiat Oncol Biol Phys. 2014 Dec 1;90(5):1168-76. doi: 10.1016/j.ijrobp.2014.08.008. Epub 2014 Oct 8.
4
Stereotactic body radiotherapy for centrally located stage I NSCLC: a multicenter analysis.立体定向体部放射治疗中央型Ⅰ期非小细胞肺癌：一项多中心分析。
Strahlenther Onkol. 2015 Feb;191(2):125-32. doi: 10.1007/s00066-014-0739-5. Epub 2014 Aug 27.
5
Toxicities of organs at risk in the mediastinal and hilar regions following stereotactic body radiotherapy for centrally located lung tumors.立体定向体部放疗治疗中央型肺部肿瘤后纵隔和肺门区域的危险器官的毒性。
J Thorac Oncol. 2014 Sep;9(9):1370-6. doi: 10.1097/JTO.0000000000000260.
6
Stereotactic ablative radiotherapy (SABR) using 70 Gy in 10 fractions for non-small cell lung cancer: exploration of clinical indications.非小细胞肺癌采用70 Gy分10次的立体定向消融放疗（SABR）：临床适应证探索
Radiother Oncol. 2014 Aug;112(2):256-61. doi: 10.1016/j.radonc.2014.07.010. Epub 2014 Aug 6.
7
The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?SRS 和 SBRT 的肿瘤放射生物学：涉及的不仅仅是 5 Rs 吗？
Int J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):254-62. doi: 10.1016/j.ijrobp.2013.07.022.
8
Dose-limiting toxicity after hypofractionated dose-escalated radiotherapy in non-small-cell lung cancer.非小细胞肺癌的亚分次剂量递增放疗后的剂量限制毒性。
J Clin Oncol. 2013 Dec 1;31(34):4343-8. doi: 10.1200/JCO.2013.51.5353. Epub 2013 Oct 21.
9
Stereotactic body radiotherapy (SBRT) in central non-small cell lung cancer (NSCLC): solid evidence or "no-go"?立体定向体部放疗（SBRT）用于中央型非小细胞肺癌（NSCLC）：确凿证据还是“禁区”？
Radiother Oncol. 2013 Oct;109(1):178-9. doi: 10.1016/j.radonc.2013.07.022. Epub 2013 Sep 7.
10
Local dose-effect relations for lung perfusion post stereotactic body radiotherapy.立体定向体部放疗后肺灌注的局部剂量效应关系。
Radiother Oncol. 2013 Jun;107(3):398-402. doi: 10.1016/j.radonc.2013.04.003. Epub 2013 Apr 23.

Cons: should a medically inoperable patient with a T2N0M0 non-small cell lung cancer central in the lung hilus be treated using stereotactic body radiotherapy?

作者信息

Nestle Ursula, Belderbos José

机构信息

1 Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany ; 2 German Cancer Consortium (DKTK), Heidelberg (partner site Freiburg), Germany ; 3 Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.

出版信息

Transl Lung Cancer Res. 2015 Oct;4(5):623-6. doi: 10.3978/j.issn.2218-6751.2015.08.07.

DOI:10.3978/j.issn.2218-6751.2015.08.07
PMID:26629432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4630511/
Abstract
摘要