Matsubara T
Arerugi. 1989 Jan;38(1):49-56.
Serum levels of soluble interleukin 2 receptor (IL-2R) were determined by a sandwich enzyme immunoassay in 42 patients during the acute phase and in 30 at the convalescent phase of Kawasaki disease, 5 with streptococcal infection, 13 with anaphylactoid purpura, 7 with various vasculitis and also in 16 healthy children. In addition, we analysed the population of peripheral blood mononuclear cells in 18 of 42 patients with KD using a fluorescence-activated cell sorter. Serum IL-2R levels in patients with KD were increased in the acute phase and return to the normal range in the convalescent phase. The increased serum IL-2R levels during the acute phase correlated with the percentage of peripheral blood helper/inducer T cells among the mononuclear cells. Serum IL-2R levels were increased in patients with measles who were examined as the infectious disease (viral) controls. However, serum IL-2R levels were increased neither in patients with anaphylactoid purpura nor in other diseases with vasculitis. These results suggest that immunological activation accompanied by the release of IL-2R from helper T cells in KD is similar measles virus infection and differs from vasculitis.
采用夹心酶免疫测定法测定了42例川崎病急性期患者、30例恢复期患者、5例链球菌感染患者、13例过敏性紫癜患者、7例各种血管炎患者以及16名健康儿童的血清可溶性白细胞介素2受体（IL-2R）水平。此外，我们使用荧光激活细胞分选仪分析了42例川崎病患者中18例的外周血单个核细胞群体。川崎病患者急性期血清IL-2R水平升高，恢复期恢复至正常范围。急性期血清IL-2R水平升高与外周血单个核细胞中辅助/诱导性T细胞百分比相关。作为传染病（病毒）对照检查的麻疹患者血清IL-2R水平升高。然而，过敏性紫癜患者和其他血管炎疾病患者的血清IL-2R水平均未升高。这些结果表明，川崎病中伴随辅助性T细胞释放IL-2R的免疫激活与麻疹病毒感染相似，与血管炎不同。
