用于眼科剂型体外生物制药评估的角膜制备
Cornea preparation for in vitro bio-pharmaceutical evaluation of ophthalmic dosage forms.
作者信息
Barrelet J, Tsacopoulos M, Buri P
出版信息
J Pharm Pharmacol. 1975 Dec;27(12):919-22. doi: 10.1111/j.2042-7158.1975.tb10248.x.
Abstract
A system has been developed for a specific biopharmaceutical purpose: testing for ophthalmic preparations, the influence of formulation on drug transport through the cornea. The apparatus is a lucite cell, divided in two compartments by a clamped rabbit cornea. Physiological conditions are ensured by a supply of oxygenated perfusion medium. They are monitored by electrical conductivity and corneal thickness measurements. Reliability of the system was tested in a set of experiments.
摘要
已开发出一种用于特定生物制药目的的系统
用于眼科制剂测试，即研究制剂对药物透过角膜的影响。该装置是一个有机玻璃小室，由一块夹着的兔角膜分隔成两个隔室。通过供应含氧灌注介质来确保生理条件。通过电导率和角膜厚度测量对这些条件进行监测。在一组实验中对该系统的可靠性进行了测试。
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