Heber-Katz E, Acha-Orbea H
Immunol Today. 1989 May;10(5):164-9. doi: 10.1016/0167-5699(89)90174-6.
Experimental allergic encephalomyelitis has been shown to have an immunological basis. In fact, the disease can be induced by T cells specific for myelin basic protein, a molecule found in abundance in the central nervous system. In this article, Ellen Heber-Katz and Hans Acha-Orbea discuss the T-cell receptor (TCR) repertoire of the encephalitogenic T-cell response, and show that a limited V gene pool, in fact a single V beta and two V alpha families, are being used by the PL/J and B10.PL mice and by every rat strain examined, even though the antigenic determinants and the major histocompatibility complex (MHC) molecules are different in all cases. This extraordinary finding suggests that the TCR is involved in encephalitogenicity in a way that not only involves the recognition of antigen in association with MHC, but also as an effector molecule that results in encephalitis. If this is true, it implies that TCRs, in general, play more than one role in mammalian physiology.
实验性变应性脑脊髓炎已被证明具有免疫学基础。事实上，这种疾病可由针对髓鞘碱性蛋白的T细胞诱发，髓鞘碱性蛋白是一种在中枢神经系统中大量存在的分子。在本文中，艾伦·赫伯 - 卡茨和汉斯·阿查 - 奥尔贝亚讨论了致脑炎性T细胞反应的T细胞受体（TCR）库，并表明PL/J和B10.PL小鼠以及所检测的每一种大鼠品系都在使用有限的V基因库，实际上是单个Vβ和两个Vα家族，尽管在所有情况下抗原决定簇和主要组织相容性复合体（MHC）分子都不同。这一非凡的发现表明，TCR参与致脑炎性的方式不仅涉及与MHC相关的抗原识别，还作为一种导致脑炎的效应分子。如果这是真的，那就意味着TCR一般在哺乳动物生理学中发挥不止一种作用。
