Kikuchi Hitomi, Hikichi Takuto, Takagi Tadayuki, Suzuki Rei, Watanabe K O, Nakamura Jun, Sugimoto Mitsuru, Waragai Yuichi, Konno Naoki, Asama Hiroyuki, Takasumi Mika, Watanabe Hiroshi, Obara Katsutoshi, Ohira Hiromasa
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine.
Fukushima J Med Sci. 2015;61(2):160-6. doi: 10.5387/fms.2015-18. Epub 2015 Dec 3.
Peppermint oil, which suppresses gastric peristalsis during esophagogastroduodenoscopy (EGD), is effective for determining the margin of a gastric tumor. This study was conducted to evaluate the utility of an L-menthol preparation for suppressing gastric peristalsis and for diagnosing gastric tumors.
The study examined 124 patients who underwent EGD between January and April 2012. After 20 mL of 0.8% L-menthol was sprayed directly onto the mucosal surface of the gastric antrum, the degree of peristalsis suppression in the antrum was evaluated. The effectiveness of L-menthol for identifying new gastric tumors and determining tumor margins was also evaluated.
Gastric peristalsis was suppressed in 88.5% (69/78) of patients, with complete suppression of peristalsis achieved in 78.2%. L-menthol exerted a higher peristalsis-suppressive effect in patients with endoscopic gastric mucosal atrophy (93.3%, 56/60) than in patients without atrophy (72.2%, 13/18) (p = .014). L-menthol application caused the detection of new gastric tumors in 1.6% (2/124) of patients and clarification of the margin of three lesions (in 3 patients) identified as having an unclear margin before L-menthol application.
These results suggest that L-menthol is effective for suppressing gastric peristalsis during EGD and suggest that it is useful for identifying gastric tumors and for determining tumor margins.
薄荷油可在食管胃十二指肠镜检查（EGD）期间抑制胃蠕动，对确定胃肿瘤边界有效。本研究旨在评估L-薄荷醇制剂在抑制胃蠕动及诊断胃肿瘤方面的效用。
该研究纳入了2012年1月至4月期间接受EGD检查的124例患者。将20毫升0.8%的L-薄荷醇直接喷洒在胃窦黏膜表面后，评估胃窦蠕动抑制程度。同时评估L-薄荷醇在识别新的胃肿瘤及确定肿瘤边界方面的有效性。
88.5%（69/78）的患者胃蠕动受到抑制，其中78.2%实现了蠕动完全抑制。与无内镜下胃黏膜萎缩的患者（72.2%，13/18）相比，L-薄荷醇在内镜下胃黏膜萎缩患者中产生了更高的蠕动抑制效果（93.3%，56/60）（p = 0.014）。应用L-薄荷醇使1.6%（2/124）的患者检测到新的胃肿瘤，并使3例（3个病变）在应用L-薄荷醇前边界不清晰的病变边界得以明确。
这些结果表明，L-薄荷醇在EGD期间抑制胃蠕动有效，且有助于识别胃肿瘤及确定肿瘤边界。
